Ibuprofen, approved for use in febrile children in 1989, is a common over-the-counter medication currently, its labeled dose is 5–10 mg/kg every 6–8 h in children aged > 6 months. Acetaminophen has a longer history, starting in the 1950s when it replaced aspirin to prevent Reye’s syndrome currently, its labeled dose is 10–15 mg/kg every 4 h in children aged > 3 months. The most commonly recommended antipyretic drugs are acetaminophen and ibuprofen. The role of antipyretic medication is to ease the child’s discomfort caused by fever and prevent dehydration. This phenomenon is called “fever phobia”. Fever is also a common reason for visiting physicians. In general, when febrile children present to a clinic, physicians focus on determining and treating the underlying cause of the pyrexia, whereas parents are more concerned about alleviating the fever itself. Fever is a crucial immune response of the body that helps us eliminate invading pathogens, and is a common symptom in various pediatric diseases, particularly infectious diseases. Nevertheless, acetaminophen is safer than ibuprofen, particularly in children approximately 5 years old.Ĭhildren experience fever more frequently than adults. Conclusions: The effects of ibuprofen are similar to acetaminophen even in children mean aged approximately 5 years old. Acetaminophen demonstrated a lower overall adverse event rates than ibuprofen (POR=0.71 95%CI: 0.58–0.87 I2=0%). However, the treatment–time interaction model for body temperature demonstrated that the fever resolution effect was mainly from the time factor based on the available data (effect size=−0.20 95%CI: −0.30 to −0.11 I2=6.9%). Pooled estimates demonstrated that acetaminophen led to significantly lower fever resolution rates than ibuprofen did (POR=0.91, 95%CI: 0.84–0.98 I2=0%) in the subgroup of trials with a mean age of <2 years. Results: In total, 26 RCTs (n=4137) fulfilled eligibility criteria. 95% confidence intervals (CIs) were also presented. Data were pooled mainly using random-effects model however, because of some sparse data, Peto odds ratios (PORs) were used for outcomes of fever resolution and adverse event. Two authors individually extracted information on trial design, demography, rate of fever resolution, body temperature, and overall adverse event. Material and methods: Cochrane, Embase, and PubMed databases were searched for the relevant RCTs. The purpose of this study was to assess the efficacy and safety of acetaminophen and ibuprofen in febrile children through a systematic review with meta-analysis of randomized controlled trials (RCTs). However, the indications for selecting an appropriate drug from the most commonly used antipyretic drugs acetaminophen and ibuprofen remain unclear. Introduction: When a child presents with fever in the clinical encounter, parents are usually concerned about alleviating the fever.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |